Design and development of polysaccharide hemostatic materials and their hemostatic mechanism. (11th October 2017)

• Record Type: Journal Article
• Authors: Yang, Xiao; Liu, Wen; Li, Na; Wang, Mingshan; Liang, Bin; Ullah, Ihsan; Luis Neve, Agnaldo; Feng, Yakai; Chen, Hao; Shi, Changcan
• Is Part Of: Biomaterials science. Volume 5:Number 12(2017:Dec.)
• Page Start: 2357
• Page End: 2368
• Publication Date: 2017-10-11
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c7bm00554g
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. Abstract : The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and the hemostasis mechanism of different materials. Among hemostatic materials, polysaccharides are naturally derived polymers having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in hemostatic applications. Furthermore, polysaccharide-based hemostatic materials with anti-microbial and healing functions are also introduced.