Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents. Issue 12 (20th October 2017)

• Record Type: Journal Article
• Authors: Shen, Kun; Wang, Qiu
• Is Part Of: Chemical science. Volume 8:Issue 12(2017)
• Page Start: 8265
• Page End: 8270
• Publication Date: 2017-10-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7sc03420b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A copper-catalyzed aminoalkynylation reaction of alkenes is developed for construction of diverse azaheterocycles and installation of an alkyne group in one step, presenting broad applications in synthesis, bioconjugation, and molecular imaging. Abstract : A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, bioconjugation, and molecular imaging.