Isopimarane-type diterpenoids from Callicarpa macrophylla vahl. (December 2017)

• Record Type: Journal Article
• Authors: Wang, Zhen-Hui; Huang, Jian; Niu, Chao; Wang, Jin-Hui; Wu, Bin
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 224
• Page End: 228
• Publication Date: 2017-12
• Subjects: Callicarpa macrophylla Vahl -- Isopimarane-type diterpenoid -- NMR -- Anti-inflammatory activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.10.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new isopimarane-type diterpenoids were isolated from the Callicarpa macrophylla Vahl. Inhibitory activity were evaluated for the isolated isopimarane-type diterpenoids. Compounds 6 and 7 exhibited potent inhibitory activity with NO inhibitory rate of 40.23–46.78%. Abstract: Three new isopimarane-type diterpenoids, named callicapene M1 (1 ), callicapene M2 (2 ), and callicapene M3 (3 ), together with four known isopimarane-type diterpenoids (4, 5, 6, 7 ), were isolated from the Callicarpa macrophylla Vahl. Their structures were elucidated by spectroscopic techniques (IR, UV, MS, 1D, 2D NMR). The isolated compounds6 and7 exhibited potent inhibitory activity with inhibition rates of 40.23–46.78% on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays.