Cytotoxic, antimicrobial activities, AChE and BChE inhibitory effects of compounds from Tanacetum chiliophyllum (Fisch. & Mey.) Schultz Bip. var. oligocephalum (D.C.) Sosn. and T. chiliophyllum (Fisch. & Mey.) Schultz Bip. var. monocephalum Grierson. (December 2017)

• Record Type: Journal Article
• Authors: Polatoğlu, Kaan; Yücel, Yasemin Yücel; Nalbantsoy, Ayşe; Yalçin, Hüsniye Tansel; Gören, Nezhun
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 199
• Page End: 204
• Publication Date: 2017-12
• Subjects: T. chiliophyllum -- AChE -- BChE -- Cytotoxic activity -- Antimicrobial activity -- Ulubelenolide; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.10.011
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Eupatilin, cirsilineol & ulubelenolide have 7.8 μg/mL MIC for C. albicans . 5-Hydroxy-3′, 4′, 6, 7-tetramethoxyflavone have 22.34 ± 0.70 IC50 for MCF-7 & HEK 293. 5-Hydroxy-3′, 4′, 7-trimethoxyflavone have 25.80 ± 0.17 IC50 for MCF-7 & HEK 293. Ulubelenolide have 80.37% & 76.99%, AChE & BChE inhibitory property respectively. Abstract: Tanacetum L. species traditionally used for insecticidal purposes as well as in folk medicine for their antitumor, antimicrobial, antifungal activities. In our previous study a novel sesquiterpene lactone and triterpene lactone together with 12 known flavonoids, coumarin and a triterpene were isolated from T. chiliophyllum var. oligocephalum and T. chiliophyllum var. monocephalum extracts which have insecticidal and antimicrobial activity. In this study, cytotoxic, antimicrobial activities and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory effects of pure compounds isolated from these plants were investigated. The tested compounds showed AChE and BChE inhibition which ranged between 7.20–80.37% and 9.19%–76.99% respectively. The highest AChE and BChE inhibition was observed for ulubelenolide which afforded 80.37% and 76.99% inhibition respectively. The cytotoxic effect of the compounds ranged between 22.34–49.77 μg/mL IC50 values. Highest cytotoxic activity was observed against MCF-7 and HEK 293 cell line by 5–hydroxy-3′, 4′, 7-trimethoxy flavone and 5-hydroxy-3′, 4′, 6, 7-tetramethoxyflavone that produced 25.80 ± 0.17 and 22.34 ± 0.70 IC50 values respectively. Compounds eupatilin, cirsilineol, 5–hydroxy-3′, 4′, 7-trimethoxy flavone and ulubelenolide showed significant antimicrobial effect on C. albicans with 7.8 μg/mL MIC. The new compound ulubelenolide afforded high AChE and BChE inhibition as well as high antifungal activity. In our opinion activity of this substance should be evaluated further against other fungal species.