Enantioseparation of Flavanoids, Isoxazolines, Dansyl Amino Acids and β‐Blockers on Native and Phenylcarbamoylated α, β and γ‐Cyclodextrin Chiral Stationary Phases. Issue 31 (3rd November 2017)

• Record Type: Journal Article
• Authors: Jin, Xuan; Kang, Qing; Wang, Yong
• Is Part Of: ChemistrySelect. Volume 2:Issue 31(2017)
• Page Start: 9992
• Page End: 9998
• Publication Date: 2017-11-03
• Subjects: cyclodextrins -- chiral stationary phase -- enantioseparation -- liquid chromatography; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701847
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: In this study, a series of native and p ‐methylphenylcarbamoylated cyclodextrin chiral stationary phases (CD‐CSPs) were developed based on α, β and γ‐cyclodextrin via ether linkage. The as‐prepared CSPs were characterized by FTIR, solid‐state C 13 NMR, thermogravimetric analysis and elemental analysis. Their enantioseparation properties were comprehensively investigated by using high performance liquid chromatography (HPLC) with various racemates including flavanoids, isoxazolines, dansyl amino acids and β‐blockers. The effects of CD cavity size and CD functionalities on the enantioseparation results were evaluated in detail. The correlation between analyte structures and their chiral resolution were also investigated. A reference chart has been proposed for quick choice of CD‐CSPs for enantioseparation of specific racemates. Abstract : In this study, a series of native and p ‐methylphenylcarbamoylated cyclodextrin chiral stationary phases (CD‐CSPs) were developed based on α, β and γ‐cyclodextrin via ether linkage. Their enantioseparation properties were investigated by using high performance liquid chromatography (HPLC) with various racemates including flavanoids, isoxazolines, dansyl amino acids and β ‐blockers. The effects of CD cavity size, CD functionalities and analyte structures on the enantioseparation results were evaluated in detail. A reference chart shows quick choice of CD‐CSPs for enantioseparation of specific racemates.