Copper‐Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines. Issue 21 (18th September 2017)

• Record Type: Journal Article
• Authors: Lan, Chunling; Tian, Zhuang; Liang, Xuchun; Gao, Mingchun; Liu, Wenting; An, Yu; Fu, Wencheng; Jiao, Guanming; Xiao, Junjie; Xu, Bin
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 21(2017)
• Page Start: 3735
• Page End: 3740
• Publication Date: 2017-09-18
• Subjects: annulation -- cinnolines -- copper -- hydrazones -- C−H functionalization -- nitrogen heterocycles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700669
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A novel method was developed for the construction of biologically active poly‐substituted cinnolines from easily accessible hydrazones in good to excellent yields. A simple copper catalyst could efficiently promote C−N bond formation through selective C−H functionalization and dehydrogenative amination. Furthermore, the inert C−Heteroatom (O/F/N) bonds are susceptible to cleavage in high selectivity in the newly developed aerobic annulation, in preference to the alternative C−H bond, which is left intact. Abstract :