Traceless Directing Group Assisted Cobalt‐Catalyzed C−H Carbonylation of Benzylamines. Issue 21 (20th September 2017)

• Record Type: Journal Article
• Authors: Ling, Fei; Ai, Chongren; Lv, Yaping; Zhong, Weihui
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 21(2017)
• Page Start: 3707
• Page End: 3712
• Publication Date: 2017-09-20
• Subjects: traceless directing group -- C−H carbonylation -- cobalt -- benzylamine -- (+)-garenoxacin; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700780
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The first example of cobalt‐catalyzed C( sp 2 )−H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N −unprotected iso‐indolinones through direct C−H/N−H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)‐garenoxacin. Abstract :