Diagnostic and prognostic value of low percentage of glycosylated ferritin in acquired hemophagocytic lymphohistiocytosis: A single‐center study. (18th July 2017)

• Record Type: Journal Article
• Authors: Nabergoj, M.; Marinova, M.; Binotto, G.; Brugnaro, L.; Zaninotto, M.; Plebani, M.; Semenzato, G.; Vianello, F.
• Is Part Of: International journal of laboratory hematology. Volume 39:Number 6(2017:Dec.)
• Page Start: 620
• Page End: 624
• Publication Date: 2017-07-18
• Subjects: differential diagnosis of hyperferritin -- glycosylated ferritin -- hemophagocytic lymphohistiocytosis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; 616.15005
• DOI: 10.1111/ijlh.12713
• Languages: English
• ISSNs: 1751-5521

Abstract

Abstract: Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life‐threatening syndrome characterized by an excessive immune activation. Glycosylated ferritin (GF) level has been proposed as highly specific of HLH. Methods: We have studied 12 subjects with HLH according to the HLH‐04 trial criteria and 11 patients with a clinical and laboratoristic suspicion of HLH. The percentage of GF was measured by an in‐house assay. Results: The only biomarkers that were significantly different in the two groups were fraction of GF ( P <.001) and the presence of hemophagocytosis in bone marrow ( P =.006). Subjects with HLH had significantly lower percentage of GF than patients with other inflammatory conditions mimicking HLH. A fraction of GF ≤20% was strongly consistent with a diagnosis of HLH. Conclusions: Fraction of GF is useful to identify subjects at high risk for early death and therefore in need of early treatment.