New flavonol glycoside from Scabiosa prolifera L. aerial parts with in vitro antioxidant and cytotoxic activities. Issue 24 (17th December 2017)

• Record Type: Journal Article
• Authors: Al-Qudah, Mahmoud A.; Otoom, Noor K.; Al-Jaber, Hala I.; Saleh, Ayman M.; Abu Zarga, Musa H.; Afifi, Fatma U.; Abu Orabi, Sultan T.
• Is Part Of: Natural product research. Volume 31:Issue 24(2017)
• Page Start: 2865
• Page End: 2874
• Publication Date: 2017-12-17
• Subjects: Scabiosa prolifera -- Dipsacaceae -- kaempferol-3-O-(4″, 6″-di-E-p-coumaroyl)-β-D-galactopyranoside -- antioxidant activity -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1305377
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4″, 6″-di-E- p -coumaroyl)-β-D-galactopyranoside (1 ), along with ten other known compounds including luteolin-7-O-(2″-O-ethyl-β-glucopyranoside), β-sitosterol, β-sitosterylglucoside, ursolic acid, corosolic acid, ursolic acid 3-O-β-D-arabinopyranoside, apigenin, methyl-α-D-glucopyranoside, luteolin-7-O-β-glucopyranoside and isoorientin. The structures of all isolated compounds were established using chemical methods and spectroscopic methods including IR, UV, NMR (1D and 2D) and HRESIMS. All compounds were isolated for the first time from the plant. The antioxidant and cytotoxic activities of compounds1 and2 were also investigated. Abstract :