Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading. Issue 41 (16th October 2017)

• Record Type: Journal Article
• Authors: Zhang, Fuwu; Khan, Sarosh; Li, Richen; Smolen, Justin A.; Zhang, Shiyi; Zhu, Guizhi; Su, Lu; Jahnke, Ashlee A.; Elsabahy, Mahmoud; Chen, Xiaoyuan; Wooley, Karen L.
• Is Part Of: Nanoscale. Volume 9:Issue 41(2017)
• Page Start: 15773
• Page End: 15777
• Publication Date: 2017-10-16
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr05935c
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Polyphosphoester-based nanoparticles are capable of loading paclitaxel chemically and physically, achieving ultrahigh equivalent paclitaxel aqueous concentrations. Abstract : Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL −1 . The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.