Synthesis and retention properties of molecularly imprinted polymers for antibiotics containing a 5-nitrofuran ring. Issue 80 (1st November 2017)

• Record Type: Journal Article
• Authors: Rusen, Edina; Diacon, Aurel; Mocanu, Alexandra; Rizea, Florica; Bucur, Bogdan; Bucur, Madalina Petruta; Radu, Gabriel-Lucian; Bacalum, Elena; Cheregi, Mihaela; David, Victor
• Is Part Of: RSC advances. Volume 7:Issue 80(2017)
• Page Start: 50844
• Page End: 50852
• Publication Date: 2017-11-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra10196a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Impedimetric sensor based on molecularly imprinted polymers synthetized for antibiotics containing a 5-nitrofuran ring. Abstract : Novel molecularly imprinted polymers (MIPs) designated for the solid-phase extraction of antibiotics containing a 5-nitrofuran ring (nitrofurantoin and furaltadone) are reported. The synthesis of these MIPs was based on commercial monomers and cross-linking agents capable of forming hydrogen bonds with the template molecules. Thus, the designed MIPs should involve acceptable costs and easier accessibility. Their retention properties were studied by solid-phase extraction (SPE) procedures and the breakthrough curves were evaluated for both imprinted and non-imprinted polymers (NIPs). Due to the presence of adsorption sites created in polymers by imprinting, the MIPs showed a significant difference in the retention property in comparison to NIPs. The MIPs were also immobilized onto a gold electrode surface by entrapment into a silane sol–gel matrix for the development of a sensor based on electrochemical impedance measurements. The good mechanical adherence of the sol–gel matrix on the gold electrode surface was achieved by formation of a self-assembled monolayer using 3-mercaptopropyl trimethoxisilane that acts as an anchoring bridge.