Palladium-catalyzed three-component tandem reaction of sulfonyl hydrazones, aryl iodides and allenes: highly stereoselective synthesis of (Z)-α-hydroxymethyl allylic sulfones. Issue 79 (30th October 2017)

• Record Type: Journal Article
• Authors: Hou, Yunlei; Shen, Qi; Zhu, Liangyu; Han, Yufei; Zhao, Yanfang; Qin, Mingze; Gong, Ping
• Is Part Of: RSC advances. Volume 7:Issue 79(2017)
• Page Start: 50372
• Page End: 50377
• Publication Date: 2017-10-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra08208h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Sulfonyl hydrazones have been identified as an excellent sulfonyl anion surrogate in the tandem reaction with aryl iodides and allenes for the synthesis of functionalized ( Z )-allylic sulfones. Abstract : Sulfonyl hydrazones have been identified as an excellent sulfonyl anion surrogate in the base and Pd 0 -catalyzed three-component tandem reaction with aryl iodides and allenes for the synthesis of functionalized allylic sulfones. By forming a stabilized six-membered palladacycle intermediate, the reaction led to the desired higher substituted allylic sulfones with excellent Z selectivities and high yields.