Justification of routine venous thromboembolism prophylaxis in head and neck cancer reconstructive surgery. Issue 12 (30th September 2017)

• Record Type: Journal Article
• Authors: Ong, Hui Shan; Gokavarapu, Sandhya; Al‐Qamachi, Laith; Yin, Min Yi; Su, Li Xin; Ji, Tong; Zhang, Chen Ping
• Is Part Of: Head & neck. Volume 39:Issue 12(2017)
• Page Start: 2450
• Page End: 2458
• Publication Date: 2017-09-30
• Subjects: head and neck neoplasm -- risk factors -- thrombolytic therapy -- thromboprophylaxis -- venous thromboembolism; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24914
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Venous thromboembolism (VTE) is a preventable complication in which early ambulation is expected after head and neck surgery. Thus, the role of VTE prophylaxis is questionable and needs further assessment. The purpose of this study was to specify the relative contributing risk factors for patients who underwent head and neck cancer ablation with immediate reconstruction. Methods: A retrospective analysis was conducted of consecutive head and neck cancer ablations with immediate reconstructions between 2008 and 2013. Dextran and prostaglandin E2 (PGE2) were routinely given as flap thromboprophylaxis. Logistic regression was applied to analyze the potentially significant risk factors. Results: Of 1953 subjects, the incidence of symptomatic VTE was 2.2% with 0.1% mortality rate. Prolonged surgery (>592.5 minutes; P = .048), immobilization (>4 days; P = .019), and subjects without postoperative flap thromboprophylaxis ( P = .002) are significant risk factors for VTE development. Conclusion: Our flap thromboprophylaxis regime might have played a crucial role in keeping the incidence of VTE low. Despite prolonged immobilization in fibula flap reconstruction, the incidence of VTE remained low when flap thromboprophylaxis was given.