Survival outcomes for postoperative chemoradiation in intermediate‐risk oral tongue cancers. Issue 12 (27th September 2017)

• Record Type: Journal Article
• Authors: Spiotto, Michael T.; Jefferson, Gina D.; Wenig, Barry; Markiewicz, Michael R.; Weichselbaum, Ralph R.; Koshy, Matthew
• Is Part Of: Head & neck. Volume 39:Issue 12(2017)
• Page Start: 2537
• Page End: 2548
• Publication Date: 2017-09-27
• Subjects: adjuvant chemoradiotherapy -- head and neck neoplasms -- radiotherapy -- tongue neoplasms; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24932
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The survival outcomes for surgery + postoperative radiotherapy (S+RT) or surgery + postoperative chemoradiation (S+CRT) was compared in patients having oral tongue cancers with intermediate‐risk pathological features. Methods: Using the National Cancer Database (NCDB), overall survival (OS) for S+RT or S+CRT was estimated using the Kaplan‐Meier methods and Cox proportional hazard models in the entire population (n = 2803) and in a propensity‐matched cohort (n = 1136). Results: The 3‐year OS was 73.3% for S+CRT versus 66.7% for S+RT ( P = .02). The S+CRT improved the 3‐year OS for patients with 2 or more involved metastatic lymph nodes (≥2 MLNs; P = .01) but not for patients with <2 MLNs ( P = .73). Undergoing S+CRT improved the 3‐year OS for patients with pathologic T classification (pT) pT3‐pT4 disease ( P = .01) but not for patients with pT1‐pT2 disease ( P = .18). Conclusion: Undergoing S+CRT was associated with improved survival for patients with tongue cancers with ≥2 MLNs and/or pT3‐pT4 suggesting that specific intermediate‐risk pathological features benefit from treatment intensification.