Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. Issue 8 (29th August 2017)

• Record Type: Journal Article
• Authors: Green, Elaine K.; Di Florio, Arianna; Forty, Liz; Gordon‐Smith, Katherine; Grozeva, Detelina; Fraser, Christine; Richards, Alexander L.; Moran, Jennifer L.; Purcell, Shaun; Sklar, Pamela; Kirov, George; Owen, Michael J.; O'Donovan, Michael C.; Craddock, Nick; Jones, Lisa; Jones, Ian R.
• Is Part Of: American journal of medical genetics. Volume 174:Issue 8(2017)
• Page Start: 767
• Page End: 771
• Publication Date: 2017-08-29
• Subjects: Research Diagnostic Criteria -- SABP -- schizoaffective disorder bipolar type -- TRAIP; Neuropsychiatry -- Periodicals; Medical genetics -- Periodicals; 616.8904205
• DOI: 10.1002/ajmg.b.32572
• Languages: English
• ISSNs: 1552-4841

Abstract

Abstract : Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC‐SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC‐SABP, we have performed a replication study using independent RDC‐SABP cases ( n = 144) and controls ( n = 6, 559), focusing on the 10 loci that reached a p ‐value <10 −5 for RDC‐SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta‐analysis (combined RDC‐SABP, n = 423, controls, n = 9, 494), we observed genome‐wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 ( p ‐value, 4.37 × 10 −8 ). This locus did not reach genome‐wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.