MicroRNA mediated regulation of immunity against gram-negative bacteria. (3rd September 2017)

• Record Type: Journal Article
• Authors: Keck, Jonathon; Gupta, Rishein; Christenson, Lane K.; Arulanandam, Bernard P.
• Is Part Of: International reviews of immunology. Volume 36:Number 5(2017)
• Page Start: 287
• Page End: 299
• Publication Date: 2017-09-03
• Subjects: Bacteria -- gram negative -- host immunity -- microRNAs; Immunology -- Periodicals; Autoimmune diseases -- Periodicals; 616.079
• DOI: 10.1080/08830185.2017.1347649
• Languages: English
• ISSNs: 0883-0185

Abstract

ABSTRACT: Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.