Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacial granulomatosis. (27th July 2017)

• Record Type: Journal Article
• Authors: Vassallo, C.; Rivetti, N.; Merlino, M.; Borroni, G.; Brazzelli, V.
• Is Part Of: Clinical and experimental dermatology. Volume 42:Number 8(2017)
• Page Start: 887
• Page End: 889
• Publication Date: 2017-07-27
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.13201
• Languages: English
• ISSNs: 0307-6938

Abstract

Summary: Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non‐necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32‐year‐old man with a 2‐year history of oedema and swelling of the upper lip without systemic symptoms. The history, clinical features and histopathological findings led to the diagnosis of cheilitis granulomatosa (CG), a disease included in the spectrum of OFG. The patient was treated with oral diaminodiphenyl sulfone (DDS) and clofazimine without success. Oral doxycycline led to a slight improvement of the disease. Because the volume of the upper lip was twice normal size, surgical reduction was performed, followed by administration of oral doxycycline for 3 months. This therapeutic approach led to complete remission, with no recurrence after 3 years.