A 5-HT1Areceptor promoter polymorphism influences fronto-limbic functional connectivity and depression severity in bipolar disorder. (30th December 2017)

• Record Type: Journal Article
• Authors: Vai, Benedetta; Riberto, Martina; Ghiglino, Davide; Poletti, Sara; Bollettini, Irene; Lorenzi, Cristina; Colombo, Cristina; Benedetti, Francesco
• Is Part Of: Psychiatry research. Volume 270(2017)
• Page Start: 1
• Page End: 7
• Publication Date: 2017-12-30
• Subjects: Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2017.09.012
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: GG patients present an higher Amy–VLPFC connectivity compared to C carriers. rs6295 moderates the relationship between Amy–VLPFC coupling and clinical outcome. Corticolimbic connectivity predicts higher depressive symptomatology in GG patients. Genetic variations in serotonergic system could affect outcome in bipolar disorder.