Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish. Issue 11 (20th August 2017)
- Record Type:
- Journal Article
- Title:
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish. Issue 11 (20th August 2017)
- Main Title:
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish
- Authors:
- Ryan, Meghann
Kochunov, Peter
Rowland, Laura M.
Mitchell, Braxton D.
Wijtenburg, S. Andrea
Fieremans, Els
Veraart, Jelle
Novikov, Dmitry S.
Du, Xiaoming
Adhikari, Bhim
Fisseha, Feven
Bruce, Heather
Chiappelli, Joshua
Sampath, Hemalatha
Ament, Seth
O'Connell, Jeffrey
Shuldiner, Alan R.
Hong, L. Elliot - Abstract:
- Abstract : Objective: To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA). Methods: Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA ( N = 64, 31 males/33 females, ages 18‐77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole‐brain average cortical thickness. Diffusion‐weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements. Results: Lipid/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and/or low‐density lipoprotein cholesterol measurements; factor two loaded on triglyceride/liver measurements; and factor three loaded on abdominal fat measurements. A two‐stage regression including age/sex (first stage) and the three factors (second stage) examined the peripheral lipid/fat effects. Factors two and three significantly contributed to WM measures after Bonferroni corrections ( P < 0.007). No factor significantly contributed to GM. Blood pressure (BP) inclusion did not meaningfully alter the lipid/fat‐WM relationship. Conclusions: Peripheral lipid/fat indicators were significantly and negatively associated with cerebral WM rather than with GM, independent of age and BP level. Dissecting the fat/lipid componentsAbstract : Objective: To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA). Methods: Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA ( N = 64, 31 males/33 females, ages 18‐77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole‐brain average cortical thickness. Diffusion‐weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements. Results: Lipid/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and/or low‐density lipoprotein cholesterol measurements; factor two loaded on triglyceride/liver measurements; and factor three loaded on abdominal fat measurements. A two‐stage regression including age/sex (first stage) and the three factors (second stage) examined the peripheral lipid/fat effects. Factors two and three significantly contributed to WM measures after Bonferroni corrections ( P < 0.007). No factor significantly contributed to GM. Blood pressure (BP) inclusion did not meaningfully alter the lipid/fat‐WM relationship. Conclusions: Peripheral lipid/fat indicators were significantly and negatively associated with cerebral WM rather than with GM, independent of age and BP level. Dissecting the fat/lipid components contributing to different brain imaging parameters may open a new understanding of the body‐brain connection through lipid metabolism. … (more)
- Is Part Of:
- Obesity. Volume 25:Issue 11(2017)
- Journal:
- Obesity
- Issue:
- Volume 25:Issue 11(2017)
- Issue Display:
- Volume 25, Issue 11 (2017)
- Year:
- 2017
- Volume:
- 25
- Issue:
- 11
- Issue Sort Value:
- 2017-0025-0011-0000
- Page Start:
- 1876
- Page End:
- 1880
- Publication Date:
- 2017-08-20
- Subjects:
- Obesity -- Periodicals
616.398005 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1930-739X ↗
http://www.obesityresearch.org ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/oby.21946 ↗
- Languages:
- English
- ISSNs:
- 1930-7381
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6196.929955
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5322.xml