Three new amino acid derivatives from edible mushroom Pleurotus ostreatus. Issue 12 (2nd December 2017)

• Record Type: Journal Article
• Authors: Lu, Xiao-Jie; Feng, Bao-Min; Chen, Shao-Fei; Zhao, Dan; Chen, Gang; Wang, Hai-Feng; Pei, Yue-Hu
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 12(2017)
• Page Start: 1160
• Page End: 1171
• Publication Date: 2017-12-02
• Subjects: Edible mushroom -- Pleurotus ostreatus -- antioxidation -- antimicrobial activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1311870
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new amino acid derivatives, oxalamido- L -phenylalanine methyl ester (1 ), oxalamido- L -leucine methyl ester (2 ), and lumichrome hydrolyzate (3 ), together with nine known compounds (4–12 ), were isolated from the solid culture of edible mushroom Pleurotus ostreatus . Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of1 and2 were established by the chiral synthesis and confirmed by circular dichroism (CD) analysis of their total synthesis products and natural isolates. All new compounds were evaluated for their antioxidant effects, antimicrobial activities, and cytotoxic activity. Compounds1–3 showed weak antifungal activities against Candida albicans with minimum inhibitory concentration (MIC) value of 500 μg/ml. Abstract :