Diabetes mellitus increased all-cause mortality rate among newly-diagnosed tuberculosis patients in an Asian population: A nationwide population-based study. (November 2017)

• Record Type: Journal Article
• Authors: Ko, Po-Yen; Lin, Shi-Dou; Hsieh, Ming-Chia; Chen, Yu-Cheng
• Is Part Of: Diabetes research and clinical practice. Volume 133(2017)
• Page Start: 115
• Page End: 123
• Publication Date: 2017-11
• Subjects: Diabetes mellitus -- Mortality -- Tuberculosis -- Taiwan; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2017.08.011
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: DM was an independent risk factor of all-cause mortality among TB patients. The one-year all-cause mortality of TB was high and increased in the past decade. TB patients with older age and male gender had higher mortality. TB patients with certain kinds of comorbidities had higher mortality. Abstract: Aims: To investigate the effect of diabetes mellitus (DM) on all-cause mortality among patients with newly-diagnosed tuberculosis (TB) in an Asian population. We also identified risk factors for mortality in these patients. Methods: The data were obtained from the National Health Insurance Research Database and included 9831 newly-diagnosed TB individuals and 1627 TB mortality cases in the period of 2000–2010. The mortality data were divided into a DM group and a non-DM group. We measured the incidence density of mortality and identified the risk factors of mortality. Results: The all-cause mortality of newly-diagnosed TB patients progressively increased with an average rate of 16.5% during 2000–2010. DM is an independent risk factor for all-cause mortality with HRs 1.17–1.27 by various models. TB patients with ages above 75 years had the highest risk of mortality (HR = 11.93) compared with those under 45 years. TB patients with heart failure, peripheral vascular disease, ischemic heart disease, cerebral vascular disease, hypertension, chronic kidney disease, pulmonary disease, liver disease, cancer, peptic ulcer disease, gout, and autoimmune disease had higher mortality compared to those without the aforementioned factors. Conclusions: The one-year all-cause mortality after TB diagnosis was high among TB patients in Taiwan and it tended to increase in the past decade. While treating these newly-diagnosed TB patients, it is crucial to detect the factors predisposing to death, such as old age, male gender, certain kinds of aforementioned factors and diabetes.