Conflicting interactions of apolipoprotein A and high density lipoprotein cholesterol with microvascular complications of type 2 diabetes. (November 2017)

• Record Type: Journal Article
• Authors: Aryan, Zahra; Afarideh, Mohsen; Ghajar, Alireza; Esteghamati, Sadaf; Esteghamati, Alireza; Nakhjavani, Manouchehr
• Is Part Of: Diabetes research and clinical practice. Volume 133(2017)
• Page Start: 131
• Page End: 141
• Publication Date: 2017-11
• Subjects: AER albumin excretion rate -- Apo A apolipoprotein A -- ApoB apolipoprotein B-100 -- BMI body mass index -- DBP diastolic blood pressure -- DNS diabetic neuropathy symptom -- eGFR estimated glomerular filtration rate -- FPG fasting plasma glucose -- FPI fasting plasma insulin -- HbA1c hemoglobin A1C -- HDL-C high density lipoprotein cholesterol -- (HOMA-IR) homeostasis model assessment for insulin resistance -- LDL-C low-density lipoprotein cholesterol -- SBP systolic blood pressure -- TG triglycerides -- T2D type 2 diabetes; Diabetes -- HDL -- LDL -- Atherosclerosis; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2017.07.037
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Serum triglyceride and Lp(a) are positively associated with microvascular complications of T2D. Among lipid variablesserum Triglyceride has the strongest association with microvascular complications of T2D. Serum Apo-A1 is weakly but positively associated with diabetic neuropathy. Assessment of serum HDL-c improves prediction of microvascular complications of T2D. Lipids can serves as microvascular-specific biomarkers. Abstract: Aims: This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D). Methods: A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. A total of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D were included. The associations and interactions of a panel of serum lipid biomarkers with the microvascular complications of T2D were investigated. Results: Serum triglyceride had the strongest association with microvascular complications of T2D (crude model: β = 0.632, P value = 0.045). Each standard deviation increment in serum TG was associated with 3.7 times increased frequency of microvascular complications. Despite high density lipoprotein cholesterol (HDL-C), serum apolipoprotein A1 (Apo A1) was positively associated with the presence of diabetic neuropathy. Each standard deviation increment in serum ApoA1 was associated with increased frequency of diabetic neuropathy (OR, 1.2, 95% CI, (1.1–1.3), P value = 0.006). The frequency of diabetic neuropathy was higher in 2nd and 3rd quartiles of serum Lp(a) compared to diabetic patients in the first quartile (OR, 5.52, 95% (1.17–25.8), P value = 0.047). Conclusions: ApoA1 but not HDL-C is straightly associated with diabetic neuropathy. Even Slight rise in serum Lp(a) is associated with increased frequency of diabetic retinopathLipid variables could serve as specific predictors of vascular complications in diabetes.