Tuneable 3D printed bioreactors for transaminations under continuous-flow. Issue 22 (11th October 2017)

• Record Type: Journal Article
• Authors: Peris, Edgar; Okafor, Obinna; Kulcinskaja, Evelina; Goodridge, Ruth; Luis, Santiago V.; Garcia-Verdugo, Eduardo; O'Reilly, Elaine; Sans, Victor
• Is Part Of: Green chemistry. Volume 19:Issue 22(2017)
• Page Start: 5345
• Page End: 5349
• Publication Date: 2017-10-11
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc02421e
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Abstract : A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic reactors and development of continuous-flow biocatalytic processes. The bioreactors showed good activity (8–20.5 μmol h −1 mgenz −1 ) in the kinetic resolution of 1-methylbenzylamine, and very good stability ( ca. 100 h under flow).