A new seco-pimarane diterpene and four new β-resorcylic acid lactones from a fungicolous Hypomyces subiculosus. Issue 82 (9th November 2017)

• Record Type: Journal Article
• Authors: Liu, Li; Liu, Ruixing; Basnet, Buddha Bahadur; Bao, Li; Han, Junjie; Ren, Jinwei; Zeng, Zhaoqing; Zhuang, Wenying; Liu, Hongwei
• Is Part Of: RSC advances. Volume 7:Issue 82(2017)
• Page Start: 51986
• Page End: 51992
• Publication Date: 2017-11-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra11365j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : One new seco-primarane diterpene and four new β-resorcylic acid lactones were isolated and identified from the fungicolous Hypomyces subiculosus . Abstract : One new pimarane diterpene (1 ) and four new β-resorcylic acid lactones (2–5 ), together with eight known compounds (6–13 ) were isolated from the solid culture of the fungicolous Hypomyces subiculosus . The structures of the new compounds were elucidated using extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS, CD experiments, and chemical means. Compound1 is a ring cleavage pimarane diterpene possessing a bicyclic ring system. All compounds were evaluated for cytotoxic activities. Only compound7 showed moderate cytotoxicity against the A549 cell line with an IC50 of 44.5 μM.