Fatal multiple organ failure in an adolescent due to community-acquired methicillin-susceptible Staphylococcus aureus ST121/agrIV lineage: case report and review. Issue 4 (November 2015)

• Record Type: Journal Article
• Authors: Rao, Qing; Shang, Weilong; Zhou, Kun; Zhou, Renjie; Rao, Xiancai
• Is Part Of: Reviews in medical microbiology. Volume 26:Issue 4(2015:Oct.)
• Publication Date: 2015-11
• Subjects: adolescent -- community-acquired -- methicillin-susceptible Staphylococcus aureus -- multiple organ failure -- Panton-Valentine leukocidin; Medical microbiology -- Periodicals; Medical microbiology; Periodicals; 616.904105
• DOI: 10.1097/MRM.0000000000000050
• Languages: English
• ISSNs: 0954-139X

Abstract

Abstract : Adolescent deaths due to Staphylococcus aureus infection are rare. We describe the case of a 17-year-old boy who died from septic multiple organ failure caused by community-acquired methicillin-susceptible S. aureus . The patient's first clinical symptom was a skin and soft tissue infection, with multiple organ failure developing 5 days afterwards. The causative organism S. aureus was further determined to carry Panton-Valentine leukocidin genes, and molecularly characterized as staphylococcal protein A ( spa ) type t159, multilocus sequence type (ST)121, and accessory gene regular ( agr ) type IV. ST121/ agr IV S. aureus is one of the minor lineages prevailing in China, and this is the first fatal case reported due to ST121/ agr IV lineage of community-acquired methicillin-susceptible S. aureus in the country.