Visible-light-mediated direct difluoromethylation of alkynoates: synthesis of 3-difluoromethylated coumarins. Issue 43 (23rd October 2017)

• Record Type: Journal Article
• Authors: Zhu, Mei; Fu, Weijun; Wang, Zhiqiang; Xu, Chen; Ji, Baoming
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 43(2017)
• Page Start: 9057
• Page End: 9060
• Publication Date: 2017-10-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02366a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed. Abstract : A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed. A well-designed photoredox system induces a single-step, regioselective installation of CF2 H onto alkynes. Difluoromethyl sulfone was used as an easy to handle CF2 H radical source to afford the desired 3-difluoromethylated coumarins in moderate to good yields via a radical-triggered tandem difluoromethylation/5- exo cyclization/ester migration process.