Lipids at membrane contact sites: cell signaling and ion transport. (13th October 2017)

• Record Type: Journal Article
• Authors: Muallem, Shmuel; Chung, Woo Young; Jha, Archana; Ahuja, Malini
• Is Part Of: EMBO reports. Volume 18:Number 11(2017)
• Page Start: 1893
• Page End: 1904
• Publication Date: 2017-10-13
• Subjects: contact sites -- ion transport -- lipid transfer -- signaling; Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.201744331
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract: Communication between organelles is essential to coordinate cellular functions and the cell's response to physiological and pathological stimuli. Organellar communication occurs at membrane contact sites (MCSs), where the endoplasmic reticulum (ER) membrane is tethered to cellular organelle membranes by specific tether proteins and where lipid transfer proteins and cell signaling proteins are located. MCSs have many cellular functions and are the sites of lipid and ion transfer between organelles and generation of second messengers. This review discusses several aspects of MCSs in the context of lipid transfer, formation of lipid domains, generation of Ca 2+ and cAMP second messengers, and regulation of ion transporters by lipids. Abstract : Communication between organelles occurs at membrane contact sites (MCSs) and allows the coordination of cellular functions and responses to various stimuli. This review discusses MCSs in the context of lipid transfer, the formation of lipid domains and Ca 2+ signaling.