Peripheral blood CD34+ cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis. (17th January 2018)

• Record Type: Journal Article
• Authors: Giordano, Domenico; Loddo, Saverio; Laganà, Antonio Simone; Coppolino, Giuseppe; Zoccali, Giuseppe; Di Benedetto, Antonino; Santamaria, Angelo; Buemi, Michele; D'Anna, Rosario
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 31:Number 2(2018)
• Page Start: 258
• Page End: 260
• Publication Date: 2018-01-17
• Subjects: Hematopoietic stem cells -- CD34 -- first trimester -- miscarriage -- peripheral blood; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1277703
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Purpose: To evaluate the levels of peripheral blood CD34 + cells in women who subsequently had a spontaneous miscarriage (SM). Materials and methods: We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th–11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34 + cells. Results: In peripheral blood of women who had SM, PAPP-A and CD34 + cells were significantly lower ( p < 0.001) compared to control group. Conclusions: CD34 + cell low level in peripheral blood is associated with increased risk of SM.