Antimicrobial sesquiterpene lactones from Artemisia sieberi. Issue 11 (2nd November 2017)

• Record Type: Journal Article
• Authors: Mohamed, Tarik A.; Hegazy, Mohamed-Elamir F.; Abd El Aty, Abeer A.; Ghabbour, Hazem A.; Alsaid, Mansour S.; Shahat, Abdelaaty A.; Paré, Paul W.
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 11(2017)
• Page Start: 1093
• Page End: 1101
• Publication Date: 2017-11-02
• Subjects: Sesquiterpenes -- Artemisia sieberi -- Asteraceae -- antimicrobial activity -- X-rays analysis; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1302939
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new sesquiterpene lactones 3 R, 8 R -dihydroxygermacr-4(15), 9(10)-dien-6 S, 7 S, 11 R H, 12, 6-olide (1 ) and 1 R, 8 S -dihydroxy-11 R, 13-dihydrobalchanin(2 ), together with two known compounds 11-epiartapshin (3 ) and 3′-hydroxygenkwanin (4 ), were isolated from Artemisia sieberi . Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities. Abstract :