Anti-inflammatory flavonol acylglycosides from the aerial part of Lindera akoensis Hayata. Issue 80 (1st November 2017)

• Record Type: Journal Article
• Authors: Huang, Hui-Chi; Yang, Chung-Ping; Wang, Sheng-Yang; Chang, Chi-I; Sung, Ping-Jyun; Huang, Guan-Jhong; Chien, Shih-Chang; Kuo, Yueh-Hsiung
• Is Part Of: RSC advances. Volume 7:Issue 80(2017)
• Page Start: 50868
• Page End: 50874
• Publication Date: 2017-11-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra09063c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Flavonol acylglycosides, linderakosides A–E (1–5 ) were characterized from L. akoensis . Compounds1, 2, and5 exhibited showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW 264.7 cell. Abstract : Five new flavonol acylglycosides, linderakosides A–E (1–5 ), together with 30 known compounds were isolated from the aerial part of Lindera akoensis Hayata. The structures were established using extensive spectroscopic analysis and comparison of NMR data with those of known compounds. The flavonol acylglycosides1, 2, and5 showed in vitro anti-inflammatory activity, which decreased LPS-stimulated nitrite production in RAW 264.7 cells. The structure activity relationships (SAR) of the flavonol acylglycoside compounds were also established to research for potential lead compounds as anti-inflammatory drugs.