Surgical and pharmacological reassignment: influence on transsexual cardiovascular risk profile. Issue 11 (5th November 2017)

• Record Type: Journal Article
• Authors: Ciccone, Marco M.; Loverro, Giuseppe; Scicchitano, Pietro; Loverro, Matteo; Ricci, Gabriella; Scaramuzzi, Francesca; Gesualdo, Michele; Zito, Annapaola; Campagna, Marcello; Moncelli, Michele; Nicolardi, Vittorio; Manca, Fabio; Boninfante, Barbara; Carbonara, Santa; Cortese, Francesca; Todarello, Orlando; Bettocchi, Carlo
• Is Part Of: Internal medicine journal. Volume 47:Issue 11(2017)
• Page Start: 1255
• Page End: 1262
• Publication Date: 2017-11-05
• Subjects: cardiovascular risk -- carotid intima‐media thickness -- flow‐mediated dilation -- transsexuals; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.13597
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Background/Aim: To evaluate and stratify early cardiovascular risk of transsexuals who underwent pharmacological and/or surgical gender reassignment. Methods: Fifty‐six transsexuals were divided into two groups: group 1 – underwent gonadectomy (orchiectomy for transwomen and hystero‐annessiectomy for transmen); group 2 – hormone replacement therapy alone. All participants underwent carotid artery intima‐media thickness (C‐IMT) and flow‐mediated vasodilation (FMD) of brachial artery evaluations. Results: FMD was lower in patients who had undergone gonadectomy compared with non‐surgically treated patients (Group 1: 5.711 vs Group 2: 7.339, P < 0.0001). Mean C‐IMT was higher in group 1 than group 2 (group 1: 0.733 vs group 2: 0.582). The duration of hormone therapy correlates positively with mean C‐IMT ( B = 0.001) and negatively with FMD (%) ( B = − 0.007). Conclusions: Cardiovascular risk, which is expressed in terms of endothelial (FMD) and morphological (C‐IMT) dysfunction, increases in subjects undergoing gonadectomy compared with those receiving cross‐sex reassignment therapy alone.