Plasmacytoid dendritic cells and type I interferon in the immunological response against warts. (24th July 2017)

• Record Type: Journal Article
• Authors: Saadeh, D.; Kurban, M.; Abbas, O.
• Is Part Of: Clinical and experimental dermatology. Volume 42:Number 8(2017)
• Page Start: 857
• Page End: 862
• Publication Date: 2017-07-24
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.13187
• Languages: English
• ISSNs: 0307-6938

Abstract

Summary : Background: Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus (HPV)‐induced skin lesions has not been well studied. Aim: To investigate pDC occurrence and activity in HPV‐induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis (EDV)‐associated lesions. Methods: In total 20 inflamed and 20 uninflamed HPV‐induced skin lesions (including 7 EDV lesions) were retrieved from our database, and the tissue was immunohistochemically tested for pDC occurrence and activity using anti‐BDCA‐2 and anti‐MxA antibodies, respectively. Results: pDCs were present in all 20 inflamed warts and absent from all 20 uninflamed cases. MxA expression was also diffuse and strong in 75% (15/20) inflamed warts, but not in any of the uninflamed warts. Conclusions: pDCs constitute a central component of the inflammatory host response in inflamed warts, possibly contributing to their regression through production of type I interferons.