Effects of Moxonidine and Low‐Calorie Diet: Cardiometabolic Benefits from Combination of Both Therapies. Issue 11 (2nd September 2017)

• Record Type: Journal Article
• Authors: Lambert, Elisabeth A.; Sari, Carolina I.; Eikelis, Nina; Phillips, Sarah E.; Grima, Mariee; Straznicky, Nora E.; Dixon, John B.; Esler, Murray; Schlaich, Markus P.; Head, Geoffrey A.; Lambert, Gavin W.
• Is Part Of: Obesity. Volume 25:Issue 11(2017)
• Page Start: 1894
• Page End: 1902
• Publication Date: 2017-09-02
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21962
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of a centrally acting sympatholytic agent, the effects of a weight loss (WL) program using a low‐calorie diet, and the effects of a combination of both. Methods: Young (18‐30 years) male subjects with overweight (BMI > 25 kg/m 2 ) were allocated to a WL program ( n = 10), a moxonidine treatment course (M; n = 10, 0.4 mg/d), a combination of both (WL + M; n = 11), or to a control (C) group ( n = 6) for 6 months. Muscle sympathetic nerve activity (MSNA), endothelial function, renal function (Cockcroft‐Gault formula), and the metabolic profile were assessed before and after intervention. Results: WL occurred in the WL and WL + M groups (−7.6 ± 1.9 kg, P < 0.001 in both). MSNA and systolic blood pressure decreased similarly in the WL, M, and WL + M groups (by ∼10 bursts/min, P < 0.001, and by ∼9 mm Hg, P < 0.05). All other parameters for the WL, C, and M groups remained unchanged. In the WL + M group, decreased total cholesterol (−0.78 ± 0.23 mmol/L, P < 0.001), decreased low‐density lipoprotein cholesterol (−0.49 ± 0.16 mmol/L, P < 0.01), decreased insulin (−6.5 ± 2.8 mmol/L, P < 0.05), and attenuated glomerular hyperfiltration (−19 ± 5 mL/min, P < 0.01) occurred. Conclusions: The combination of moxonidine with a WL program has beneficial effects on aspects of the metabolic profile and end organ damage in young males with overweight.