Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?. Issue 5 (November 2017)

• Record Type: Journal Article
• Authors: Herbemont, Charlene; Sarandi, Solmaz; Boujenah, Jeremy; Cedrin-Durnerin, Isabelle; Sermondade, Nathalie; Vivot, Alexandre; Poncelet, Christophe; Grynberg, Michael; Sifer, Christophe
• Is Part Of: Reproductive biomedicine online. Volume 35:Issue 5(2017)
• Page Start: 521
• Page End: 528
• Publication Date: 2017-11
• Subjects: Cleavage stage embryo quality -- Extended culture -- Good-quality blastocyst -- Implantation rate -- Live birth rate; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2017.07.014
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Clinical outcomes of 291 day-5 blastocyst transfers carried out between January 2012 and March 2016 were retrospectively compared according to their quality at day 2 and 3. Inclusion criteria were female age younger than 37 years; first or second IVF and intracytoplasmic sperm injection cycle; quality of the transferred blastocyst: blastocoele B3 or higher; inner-cell-mass A/B; trophectoderm A/B; and known implantation outcome for each transferred blastocyst. Blastocysts were classified into good-quality and poor-quality embryo groups at day 2 and 3. Implantation (38.7% versus 41.4), clinical pregnancy (40.3% versus 45.9%), miscarriage (22.2% versus 26.7%;) and live birth rates (37.4% versus 38.8%) were comparable in day 2 good and poor-quality embryo groups. No signficiant differences in morphology of transferred blastocysts at day 3 were found. Multivariable analysis highlighted that poor or good embryo quality at day 2 and day 3 were not predictive of the implantation of good-quality blastocysts (at day 2: adjusted odds ratio = 0.82 CI 95% 0.49 to 1.38; at day 3: adjusted odds ratio = 1.39; CI 95% 0.77 to 2.52). Good-quality blastocyst transfer should, therefore, be carried out irrespective of embryo quality at cleavage stage, as it may not compromise success rates in a good-prognosis population.