Programmable fusion of liposomes mediated by lipidated PNA. Issue 87 (18th October 2017) - Rabe, A.
Abstract : Lipidated peptide nucleic acids as tools for efficient liposome fusion at elevated temperatures – in a zipper and a double-zipper fusion design. An potent alternative to DNA-mediated membrane fusion. Abstract : We recently reported a DNA-programmed fusion cascade enabling the use of liposomes as nanoreactors for compartmentalized chemical reactions. This communication reports an alternative and robust strategy based on lipidated peptide nucleic acids (LiPs). LiPs enabled fusion of liposomes with remarkable 31% efficiency at 50 °C with low leakage (5%).