Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Salma-Ancane, Kristine; Stipniece, Liga; Putnins, Andris; Berzina-Cimdina, Liga
• Is Part Of: Ceramics international. Volume 41:Issue 3(2015)Part B
• Page Start: 4996
• Page End: 5004
• Publication Date: 2015-04
• Subjects: β-tricalcium phosphate -- Porous bioceramic -- Magnesium substitution; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2014.12.065
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Apatitic tricalcium phosphate (ap-TCP) powders containing Mg were synthesized through wet chemical precipitation method from CaO and H3 PO4, using MgO as the source of Mg substitution. The influence of small, close to bone-like amounts of Mg on the thermal stability and specific surface area (SSA) of as-synthesized ap-TCP powders was evaluated. The increase in Mg content up to 0.674±0.080 wt% promoted enlarging of SSA of the as-synthesized powders between 91.3 m 2 /g and 104.2 m 2 /g and the stabilization of the β-tricalcium phosphate (β-TCP) phase up to 1360 °C. The effect of Mg substitution on porosity and microstructure was investigated. Interconnected porous Mg-containing β-TCP scaffolds, with micro-, macroporous structures were developed by an in situ foaming of viscous mass of proper slurry prepared of the as-synthesized ap-TCP powders, using NH4 HCO3 as a foaming agent, and subsequent sintering at 1150 °C for 2 h. The self-dissolution behavior in vitro was evaluated through soaking of scaffolds in SBF. The release of Ca and Mg ions from the 3D micro-, macroporous β-TCP scaffolds containing various amounts of Mg was determined by a complexometric (EDTA) titration. The samples with increased Mg concentrations showed significantly enhanced Mg-release rate in comparison to the samples with lower Mg substitution level.