Efficient one pot and chemoselective synthesis of functionalized 3-bromo-4, 5-dihydroisoxazole derivatives via 1, 3-dipolar cycloaddition reactions of nitrile oxides. Issue 48 (30th November 2017)

• Record Type: Journal Article
• Authors: Alizadeh, Abdolali; Roosta, Atefeh; Rezaiyehrad, Reza; Halvagar, Mohammadreza
• Is Part Of: Tetrahedron. Volume 73:Issue 48(2017)
• Page Start: 6706
• Page End: 6711
• Publication Date: 2017-11-30
• Subjects: 4-Oxo-4H-chromene-3-carbaldehyde -- 1-Phenyl-2-(1, 1, 1-triphenyl-λ5-phosphanylidene)ethan-1-one -- Dibromoformaldoxime -- 4, 5-Dihydroisoxazole -- Chemoselective -- One pot -- Multicomponent reactions; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.10.003
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A novel, metal-free and chemoselective approach for the synthesis of 4, 5-dihydroisoxazole derivatives has been developed by the reaction of readily accessible starting materials including 4-oxo-4 H -chromene-3-carbaldehyde, 1-phenyl-2-(1, 1, 1-triphenyl- λ 5 -phosphanylidene)ethan-1-one and dibromoformaldoxime under mild conditions in the presence of KHCO3 . Graphical abstract: