Altered brain correlates of response inhibition and error processing in females with obesity and sweet food addiction: A functional magnetic imaging study. Issue 6 (November 2017)

• Record Type: Journal Article
• Authors: Hsu, Jui-Sheng; Wang, Peng-Wei; Ko, Chih-Hung; Hsieh, Tsyh-Jyi; Chen, Chiao-Yun; Yen, Ju-Yu
• Is Part Of: Obesity research & clinical practice. Volume 11:Issue 6(2017:Nov./Dec.)
• Page Start: 677
• Page End: 686
• Publication Date: 2017-11
• Subjects: Obesity -- Sweet food addiction -- Response inhibition -- Impulsivity -- Error processing -- Insula; Obesity -- Research -- Periodicals; Obesity -- Treatment -- Periodicals; Obesity -- Periodicals; Obésité -- Recherche -- Périodiques; Obésité -- Traitement -- Périodiques; Obesity -- Research; Obesity -- Treatment; Electronic journals; Periodicals; 616.398
• DOI: 10.1016/j.orcp.2017.04.011
• Languages: English
• ISSNs: 1871-403X

Abstract

Highlights: The obesity women with sweet food addiction (SFA) had a higher impulsivity. They activated lower for response inhibition over rolandic operculum and thalamus. They activated higher for error processing over precuneus, insular, and putamen. Summary: Background: The aim of the present study was to evaluate the impulsivity and brain correlates of response inhibition and error processing among females with obesity and sweet food addiction (O & SFA). Methods: We evaluated the response inhibition and error processing by functional magnetic resonance imaging (fMRI) in subjects with O & SFA and controls. Twenty females with O & SFA and 20 controls were recruited. All subjects performed the event-related designed Go/No-go task under fMRI and completed questionnaires related to food craving and impulsivity. Results: The O & SFA group exhibited a higher score for impulsivity than did the control group. The O & SFA also exhibited lower brain activation when processing response inhibition over the right rolandic operculum and thalamus than controls. Both O & SFA and control groups exhibited activation of the insula and caudate during error processing. The activation over the left insula, precuneus, and bilateral putamen were higher in the subjects with O & SFA than for those in the control group. Conclusion: Our results support the fact that the fronto-striatal network is involved in response inhibition, and the caudate and insula contributes to error processing. Furthermore, women with O & SFA have impaired rolandic operculum when processing response inhibition and have greater insular and putamen activation in maintain their error processing function.