EASI‐IMS an expedite and secure technique to screen for 25I‐NBOH in blotter papers. (31st August 2017)

• Record Type: Journal Article
• Authors: de Morais, Damila Rodrigues; Barbosa, Ingrid Lopes; Cunha, Kelly Francisco; Tripodi, Guilherme Lucas; Angolini, Célio Fernando Figueiredo; Franco, Marcos Fernando; de Aquino, Elvis Medeiros; Eberlin, Marcos Nogueira; Costa, Jose Luiz
• Is Part Of: Journal of mass spectrometry. Volume 52:Number 10(2017)
• Page Start: 701
• Page End: 706
• Publication Date: 2017-08-31
• Subjects: 25I‐NBOH -- blotter papers -- EASI -- forensic chemistry -- NPS -- phenethylamine derivatives; Mass spectrometry -- Periodicals; 543.65
• DOI: 10.1002/jms.3977
• Languages: English
• ISSNs: 1076-5174

Abstract

Abstract: The increasing number of new psychoactive substances (NPS) and their quick worldwide spreading, often only slightly modified in the form of new derivatives and analogues, have brought the need for fast, wide‐ranging, and unequivocal identification methods in clinical and forensic investigations. Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC‐MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I‐NBOH (N‐(2‐hydroxybenzyl)‐2‐(4‐iodo‐2, 5‐dimethoxyphenyl)ethan‐1‐aminium), however, GC‐MS analysis of an blotter paper extract leads to incorrect results. In this work, we investigated whether easy ambient sonic‐spray mass spectrometry imaging (EASI‐IMS), and ambient ionization MS method can be applied directly to the surface of the sample requiring therefore no extraction or sample preparations, would serve as an efficient, sensitive, and secure alternative for 25I‐NBOH screening.