Effector memory and late memory T cells accumulate in the blood of CMV‐carrying individuals but not in their cerebrospinal fluid. Issue 4 (7th February 2013)

• Record Type: Journal Article
• Authors: de Jongste, Adriaan H. C.; de Graaf, Marieke T.; van den Broek, Patricia D. M.; Kraan, Jaco; Sillevis Smitt, Peter A. E.; Gratama, Jan W.
• Is Part Of: Cytometry. Volume 84B:Issue 4(2013)
• Page Start: 218
• Page End: 221
• Publication Date: 2013-02-07
• Subjects: cerebrospinal fluid -- cytomegalovirus -- flow cytometry -- T cell -- immunology; Flow cytometry -- Diagnostic use -- Periodicals; Cytodiagnosis -- Periodicals; 616.07582
• DOI: 10.1002/cyto.b.21073
• Languages: English
• ISSNs: 1552-4949

Abstract

Abstract : Cytomegalovirus (CMV)‐carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non‐carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV‐carrying individuals, we characterized CD4 + and CD8 + T‐cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non‐carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals. © 2013 International Clinical Cytometry Society