Synthesis, characterization, DNA binding and cleavage activity of homoleptic zinc(II) β-oxodithioester chelate complexes. Issue 18 (17th September 2017)

• Record Type: Journal Article
• Authors: Yadav, Manoj Kumar; Maurya, Akhilendra Kumar; Rajput, Gunjan; Manar, Krishna Kumar; Vinayak, Manjula; Drew, Michael G. B.; Singh, Nanhai
• Is Part Of: Journal of coordination chemistry. Volume 70:Issue 18(2017)
• Page Start: 3171
• Page End: 3185
• Publication Date: 2017-09-17
• Subjects: Anticancer activity -- DNA Binding -- DNA Cleavage -- zinc(II) β-oxodithioester; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2017.1377835
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: New homoleptic zinc(II) complexes, [Zn(L)2 ], where L = methyl-3-hydroxy-(3-pyridyl)-2-propenedithioate L11, and methyl-3-hydroxy-(4-pyridyl)-2-propenedithioate L22, have been synthesized and characterized by elemental (C, H, and N) analysis, ESI-MS, and (IR, UV–vis, NMR) spectroscopy; the structure of1 has been deduced by X-ray crystallography. The DNA binding and cleavage activity of the complexes have been studied. The cleavage potential of pBR322 DNA by1 and2 has been checked. Complex1, which contains nitrogen of the pyridine group in the 3-position enhances DNA cleavage potential in the presence of ascorbic acid; however, the complex is protective against DNA cleavage in the presence of DMSO or H2 O2 . Also, 1 causes cytotoxicity against the MCF-7 breast cancer cell line. The efficient cytotoxic activity and DNA cleavage ability of1 in the presence of ascorbic acid shows its potential anticancer properties and the need for further investigations of its potential as an anticancer drug. Abstract :