More challenges ahead—metabolic heterogeneity of pancreatic cancer stem cells. (3rd March 2016)

• Record Type: Journal Article
• Authors: Heeschen, Christopher; Sancho, Patricia
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 2(2016)
• Publication Date: 2016-03-03
• Subjects: Cancer stem cells -- metabolism -- metformin -- pancreatic ductal adenocarcinoma; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1105353
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified a subset of CSCs with reduced mitochondrial content that showed resistance to mitochondrial targeting, but could be sensitized by inhibition of MYC.