Novel production and characterization of porous calcium phosphate suitable for bone tissue engineering applications. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Stergioudi, F.; Choleridis, A.; Paulidou, E.; Smyrnaios, E.; Michailidis, N.
• Is Part Of: Ceramics international. Volume 41:Issue 3(2015)Part A
• Page Start: 3822
• Page End: 3832
• Publication Date: 2015-04
• Subjects: A. Sintering -- C. Mechanical properties -- D. Apatite -- E. Biomedical applications; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2014.11.058
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Porous calcium phosphate materials have found enormous use in biomedical applications including hard tissue regeneration. In this study, tailored made open-cell porous calcium phosphate samples were produced by employing a novel dissolution sintering process, using crystalline raw cane sugar as a leachable pore former material. The process parameters of the production stages were properly adjusted to optimise the quality and structure of open-cell porous calcium phosphatesamples. The influence of sintering conditions on the macro and micro-structure of the resultant porous product is investigated with a view to produce high-quality and strong porous calcium phosphate samples. Preliminary in-vitro biodegradation results indicate formation of a bone-like apatite on the porous samples surface. Mechanical performance of the produced porous calcium phosphate samples is interesting and dictates their potential use as low load-bearing implants for hard tissue replacement or as filling materials and scaffolds for cancellous bone defects repairs.