18F-FDG and 18F-Florbetapir PET in Clinical Practice: Regional Analysis in Mild Cognitive Impairment and Alzheimer Disease. (February 2015)

• Record Type: Journal Article
• Authors: Bailly, Matthieu; Ribeiro, Maria Joao Santiago; Vercouillie, Johny; Hommet, Caroline; Gissot, Valérie; Camus, Vincent; Guilloteau, Denis
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 2(2015)
• Publication Date: 2015-02
• Subjects: PET -- 18F-AV45 -- florbetapir -- 18F-FDG -- MCI -- Alzheimer disease; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000666
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Objective: The aim of this study is to compare regional cerebral metabolic rate of glucose metabolism and amyloid-β density in patients with Alzheimer disease (AD), mild cognitive impairment (MCI), and healthy elderly subjects. Methods: Eighteen patients (including 6 AD, 5 amnestic MCI, and 7 controls) were enrolled at the University Hospital of Tours, France, and submitted to clinical, neuropsychological, and MRI examinations. PET images using 18 F-florbetapir (266 MBq) and 18 F-FDG (185 MBq) were acquired. SUV ratios in specific regions were defined using PMOD3.2 software. Results: The mean values of 18 F-FDG SUV ratio were significantly lower in frontal, anterior cingulate, and temporal regions in MCI patients than in normal elderly (−15%, −22%, and −11%, respectively). Alzheimer disease patients showed global cerebral metabolic rate of glucose metabolism decrease, especially in parietal and precuneus regions (−15% and −13% compared with healthy control subjects). Only precuneus cortex showed an increased 18 F-florbetapir uptake in AD. There was no other significant regional difference in the amyloid-β density. Conclusions: In this study, we observed regional brain metabolic changes between MCI, AD, and controls, whereas only precuneus showed an increased amyloid-β density in AD. 18 F-florbetapir PET analysis needs to be visual and global, whereas 18 F-FDG analysis can be regional.