Performance of 18F-Fluoride PET or PET/CT for the Detection of Bone Metastases: A Meta-analysis. (February 2015)

• Record Type: Journal Article
• Authors: Shen, Chen-Tian; Qiu, Zhong-Ling; Han, Ting-Ting; Luo, Quan-Yong
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 2(2015)
• Publication Date: 2015-02
• Subjects: 18F-fluoride PET -- bone metastases -- bone scintigraphy -- 18F-FDG PET/CT -- meta-analysis; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000592
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Purpose: This study aimed to evaluate the diagnostic accuracy of 18 F-fluoride PET or PET/CT compared with 99m Tc-MDP bone scintigraphy and 18 F-FDG PET/CT in the detection of bone metastases. Patients and Methods: An electronic search was conducted using PubMed/MEDLINE and EMBASE. The methodological quality of the included studies was assessed with Quality Assessment of Diagnostic Accuracy Studies 2. All analyses were performed on Stata version 12.0 and Meta-DiSc version 1.4. Results: Twenty articles containing 1170 patients were identified. On a patient basis, the pooled sensitivity, specificity, and the area under the summary receiver operating characteristic curve of 18 F-fluoride PET or PET/CT were 92% (95% confidence interval [CI], 89%–95%), 93% (95% CI, 91%–95%), and 0.985, respectively. On a lesion basis, the pooled sensitivity, specificity, and area under the summary receiver operating characteristic curve of 18 F-fluoride PET or PET/CT were 87% (95% CI, 85%–88%), 95% (95% CI, 94%–96%), and 0.979, respectively. When compared with 99m Tc-MDP bone scintigraphy, 18 F-fluoride PET or PET/CT showed both higher sensitivity (96% vs. 88%, P = 0.002) and specificity (91% vs. 80%, P = 0.001). When compared with 18 F-FDG PET/CT, 18 F-fluoride PET/CT showed higher sensitivity (94% vs. 73%, P = 0.003), whereas no significant difference was observed in specificity (88% vs. 98%, P = 0.06). Conclusions: 18 F-fluoride PET or PET/CT has an excellent diagnostic capacity for the detection of bone metastases and shows advantages when compared with 99m Tc-MDP bone scintigraphy and 18 F-FDG PET/CT.