Malignant Melanocytic Matricoma: A Report of 2 Cases and Review of the Literature. (January 2016)

• Record Type: Journal Article
• Authors: Ardakani, Nima Mesbah; Palmer, David L. G.; Wood, Benjamin A.
• Is Part Of: American journal of dermatopathology. Volume 38:Number 1(2016)
• Publication Date: 2016-01
• Subjects: dendritic melanocytes -- melanocytic matricoma -- malignant matricoma -- matrical carcinoma -- beta-catenin; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000000329
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Background: To describe 2 cases of melanocytic matricoma with malignant histological features and systematically review previously reported cases of malignant melanocytic matricoma. Methods: Two cases of malignant melanocytic matricoma were identified from the practice of the authors. Additional 3 cases were identified in the literature. The clinical and pathological features of these 5 cases are described. Results: Malignant melanocytic matricoma occurs predominantly in sun-damaged skin of elderly individuals. The tumor is composed of atypical epithelial cells with brisk mitotic activity showing evidence of matrical keratinization and widespread positivity with beta-catenin. There is an admixed cytologically bland dendritic melanocytic component. To date, local recurrence has occurred in one case, but no cases of disseminated disease or death have been reported. Conclusions: Recognition of this rare tumor and separation from a range of diagnostic mimics is important to ensure adequate treatment by local excision and to allow further cases to be identified to better define the biological potential of this lesion.