Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies. (July 2015)

• Record Type: Journal Article
• Authors: Stucke, Emily M.; Clarridge, Katherine E.; Collins, Margaret H.; Henderson, Carol J.; Martin, Lisa J.; Rothenberg, Marc E.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 61(2015)Supplement 1
• Publication Date: 2015-07
• Subjects: diagnosis -- eosinophilic esophagitis -- pathologist; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000000740
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ∼5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ∼22% may yield a potential EoE diagnosis. Abstract : Supplemental Digital Content is available in the text