Endometrial Involvement in Pseudomyxoma Peritonei Secondary to Low-Grade Appendiceal Mucinous Neoplasm: Report of 2 Cases. (May 2015)

• Record Type: Journal Article
• Authors: McVeigh, Gerard; Shah, Varsha; Longacre, Teri A.; McCluggage, W. Glenn
• Is Part Of: International journal of gynecological pathology. Volume 34:Number 3(2015:May)
• Publication Date: 2015-05
• Subjects: Endometrium -- Pseudomyoma peritonei -- Low-grade appendiceal mucinous neoplasm -- Immunohistochemistry; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000149
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Pseudomyxoma peritonei is a clinical condition characterized by the presence of mucinous ascites, usually with variable amounts of neoplastic enteric-type mucinous epithelium, and most commonly secondary to spread from a low-grade appendiceal mucinous neoplasm. We report 2 cases of pseudomyxoma peritonei associated with low-grade appendiceal mucinous neoplasms where there was colonization of the endometrium (both cases) and cervical mucosa (1 case) by low-grade atypical enteric-type mucinous epithelium (CK20 positive and CK7 negative). The patients had symptoms of mucoid vaginal discharge and endometrial biopsies in both (1 patient had multiple endometrial biopsies over a period of 11 mo) and were initially interpreted as representing mucinous metaplasia. Pseudomyxoma peritonei may rarely result in endometrial and cervical mucosal involvement, presumably secondary to transtubal spread.