Effect of liquid properties on swallowing and ventilation coordination in rats. Issue 11 (28th June 2017)

• Record Type: Journal Article
• Authors: Desombres, A. C.; Duclos, C.; Ghannouchi, I.; Marie, J. P.; Verin, E.
• Is Part Of: Neurogastroenterology & motility. Volume 29:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-06-28
• Subjects: afferents -- animal -- dysphagia -- swallowing disorders -- ventilation; Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.13130
• Languages: English
• ISSNs: 1350-1925

Abstract

Abstract: Background: One aspect of rehabilitation in swallowing disorders is to change liquid properties. The objective of our study was to test how liquid properties could improve oropharyngeal dysphagia and swallowing and ventilation coordination in an animal model. Methods: Forty‐two healthy male rats were distributed in six groups, including a control group. Rats were deprived of water for 24 h and then each group was administered liquid with different properties: tap water, sugar water, sparkling water, salt water, cold water, and acidic water. Rats were studied without and with oropharyngeal dysphagia achieved by unilateral section of the hypoglossal nerve. Swallowing and ventilation were analyzed by barometric plethysmograph. Key Results: In healthy rats, swallowing occurred during expiratory time for all liquid properties. Most deglutitions were during expiratory time for all liquid properties (88±12%) and were not modified. There was an increase in VT/TI during swallowing with sparkling water and cold water ( P <.05). In the operated groups, rats had significantly fewer swallows with tap water ( P <.05) and significantly more swallows with sparkling water ( P <.001), sugar water ( P <.001) and cold water ( P< .001) during expiratory time. The mean inspiratory volume (VT/TI) increased with sparkling water ( P <.05). Conclusion and Inferences: Sparkling water seemed to improve swallowing and ventilation coordination in an animal model, to be confirmed in a study including patients with oropharyngeal dysphagia. Abstract : Swallowing and ventilation coordination could explain some oropharyngeal dysphagia. In an animal model, we demonstrated that liquid properties could improve this coordination.