Carbohydrate conjugation through microwave-assisted functionalization of single-walled carbon nanotubes using perfluorophenyl azides. (20th March 2015)

• Record Type: Journal Article
• Authors: Kong, Na; Shimpi, Manishkumar R.; Ramström, Olof; Yan, Mingdi
• Is Part Of: Carbohydrate research. Volume 405(2015)
• Page Start: 33
• Page End: 38
• Publication Date: 2015-03-20
• Subjects: Single-walled carbon nanotubes -- Microwave -- Perfluorophenyl azide -- Covalent functionalization -- Carbohydrate -- Lectin; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2014.09.006
• Languages: English
• ISSNs: 0008-6215

Abstract

Graphical abstract: Highlights: A general and effective method to functionalize pristine SWNTs. Microwave radiation greatly facilitated reaction kinetics. Carbohydrate–SWNT conjugates showed good bioaffinity and binding selectivity. Abstract: Carbohydrate–functionalized single-walled carbon nanotubes (SWNTs) were synthesized using microwave-assisted reaction of perfluorophenyl azide with the nanotubes. The results showed that microwave radiation provides a rapid and effective means to covalently attach carbohydrates to SWNTs, producing carbohydrate–SWNT conjugates for biorecognition. The carbohydrate–functionalized SWNTs were furthermore shown to interact specifically with cognate carbohydrate-specific proteins (lectins), resulting in predicted recognition patterns. The carbohydrate-presenting SWNTs constitute a new platform for sensitive protein- or cell recognition, which pave the way for glycoconjugated carbon nanomaterials in biorecognition applications.